Curriculum
Vitae
Research
Interest
Atherosclerosis,
oral mimetic peptides, functional assays for lipoproteins.
Representative
Publications
Reddy
S, Hama S, Grijalva V, Hassan K, Mottahedeh R, Hough G, Wadleigh
DJ, Navab M, Fogelman AM. Mitogen-activated protein kinase
phosphatase 1 activity is necessary for oxidized phospholipids
to induce monocyte chemotactic activity in human aortic
endothelial cells. J Biol Chem. 2001, 276:17030-5.
Garber
DW, Datta G, Chaddha M, Palgunachari MN, Hama SY, Navab M,
Fogelman AM, Segrest JP, Anantharamaiah GM. A new synthetic
class A amphipathic peptide analogue protects mice from
diet-induced atherosclerosis. J Lipid Res. 2001, 42:545-52.
Reddy
ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih
DM, Lusis AJ, Navab M, Fogelman AM. Human paraoxonase-3 is an
HDL-associated enzyme with biological activity similar to
paraoxonase-1 protein but is not regulated by oxidized lipids.
Arterioscler Thromb Vasc Biol. 2001, 21:542-7.
Van
Lenten BJ, Wagner AC, Nayak DP, Hama S, Navab M, Fogelman AM.
High-density lipoprotein loses its anti-inflammatory properties
during acute influenza a infection. Circulation.
2001,103:2283-8.
Dwyer
JH, Navab M, Dwyer KM, Hassan K, Sun P, Shircore A, Hama-Levy S,
Hough G, Wang X, Drake T, Merz CN, Fogelman AM. Oxygenated
carotenoid lutein and progression of early atherosclerosis: the
Los Angeles atherosclerosis study. Circulation. 2001,
103:2922-7.
Datta
G, Chaddha M, Hama S, Navab M, Fogelman AM, Garber DW, Mishra VK,
Epand RM, Epand RF, Lund-Katz S, Phillips MC, Segrest JP,
Anantharamaiah GM. Effects of increasing hydrophobicity on the
physical-chemical and biological properties of a class A
amphipathic helical peptide. J Lipid Res. 2001, 42:1096-104.
Navab
M, Hama SY, Hough GP, Subbanagounder G, Reddy ST, Fogelman AM. A
cell-free assay for detecting HDL that is dysfunctional in
preventing the formation of or inactivating oxidized
phospholipids. J Lipid Res. 2001, 42:1308-17.
Ng
CJ, Wadleigh DJ, Gangopadhyay A, Hama S, Grijalva VR, Navab M,
Fogelman AM, Reddy ST. Paraoxonase-2 is a ubiquitously expressed
protein with antioxidant properties and is capable of preventing
cell-mediated oxidative modification of low density lipoprotein.
J Biol Chem. 2001, 276:44444-9.
Honda
HM, Hsiai T, Wortham CM, Chen M, Lin H, Navab M, Demer LL. A
complex flow pattern of low shear stress and flow reversal
promotes monocyte binding to endothelial cells. Atherosclerosis.
2001, 158:385-90.
Hsiai
TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM.
Pulsatile flow regulates monocyte adhesion to oxidized
lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol.
2001, 21:1770-6.
Navab
M, Anantharamaiah GM, Hama S, G arber DW, Chaddha M, Hough G,
Lallone R, Fogelman AM. Oral administration of an Apo A-I
mimetic Peptide synthesized from D-amino acids dramatically
reduces atherosclerosis in mice independent of plasma
cholesterol. Circulation. 2002, 105:290-2.
Shi
W, Wang X, Shih DM, Laubach VE, Navab M, Lusis AJ. Paradoxical
reduction of fatty streak formation in mice lacking endothelial
nitric oxide synthase. Circulation. 2002,105:2078-82.
Rahmani
M, Raiszadeh F, Allahverdian S, Kiaii S, Navab M, Azizi F.
Coronary artery disease is associated with the ratio of
apolipoprotein A-I/B and serum concentration of apolipoprotein
B, but not with paraoxonase enzyme activity in Iranian subjects.
Atherosclerosis. 2002, 162:381-9.
Hsiai
TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM.
Endothelial cell dynamics under pulsating flows: significance of
high versus low shear stress slew rates (d(tau)/dt). Ann Biomed
Eng. 2002, 30:646-56.
Van
Lenten BJ, Wagner AC, Anantharamaiah GM, Garber DW, Fishbein MC,
Adhikary L, Nayak DP, Hama S, Navab M, Fogelman AM. Influenza
infection promotes macrophage traffic into arteries of mice that
is prevented by D-4F, an apolipoprotein A-I mimetic peptide.
Circulation. 2002, 106:1127-32.
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